| 초록 |
Development of bioadhesive for tissue fixation and wound care remains a challenge. A number of commercial bioadhesive products based both on natural and synthetic materials are available on the market. Either type of bioadhesive, however, suffers from several drawbacks including weak adhesion or toxicity. In this study, we present a novel mussel-inspired synthetic adhesive based on dopamine and hydrophobic n-alkylamine (lauryl, octyl, hexyl and butyl) modified polyaspartamide derivatives, which shows very strong binding ability toward various kinds of substrates such as paper, glass and metals as well as several common plastics. Additionally, the effect of adding cross-linking reagent such as NaIO4 or metal ion (Mg+2, Ca+2) on the adhesion performance was investigated. This novel and biocompatible polymer glue system has potential in various applications including medical tissue adhesive and sealant. |
