| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Fortifying angiogenic efficacy of conditioned media usingphototoxic-free blue light for wound healing. |
| 초록 | We used a blue organic lightemitting diode (bOLED) to increase the paracrine factors secreted from humanadipose-derived stem cells (hADSCs) for producing conditioned medium (CM). Ourresults showed that while the bOLED irradiation promotes a mild-dose reactive oxygengeneration that enhances theangiogenic paracrine secretion of hADSCs, it does not induce phototoxicity. The bOLED enhances paracrine factors via a cell-signalingmechanism involving hypoxia inducible factor 1 alpha. This study demonstratedthat the CM resulting from bOLED treatment shows improved therapeutic effectson mouse wound-healing models. This method contributesto overcoming the barriers to stem-cell therapies, including the toxicity andlow yields from other methods such as nanoparticles, synthetic polymers, and even cell-derived vesicles. |
| 저자 | 현지유, 방석호 |
| 소속 | 성균관대 |
| 키워드 | Angiogenesis; bOLED; conditioned medium; phototoxicity; ROS |
