| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Designer polymers for improved non-viral gene transfection |
| 초록 |
Modern therapies tend to move toward customized treatments that require high specificity and minimal side effect. Biological drugs such as proteins and nucleic acids have been considered as next generation therapeutics. Gene therapy holds enormous potential for therapeutic intervention of a broad range of genetic diseases, including infectious diseases, gene-related disorders, and cancer. Improving gene transfer efficiency is prerequisite for successful clinical gene therapy. To address the needs, polymeric gene carriers should be carefully designed to overcome several delivery barriers. In this study, we developed multifunctional non-viral vectors tailored to meet specific needs of genetic drugs, such as intracellualr distribution of plasmid DNA or siRNA. The synthetic carriers showed the way of improving tranfection efficiency by mimicking viral infection mechnisms. |
| 저자 |
정지훈1, 김선화2, 박태관3, 김성완4
|
| 소속 |
1성균관대, 2연세대, 3한국과학기술원, 4Univ. of Utah |
| 키워드 |
gene delivery; non-viral carrier; siRNA; plasmid DNA
|
| E-Mail |
|
