| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 |
13권 1호, p.228 |
| 발표분야 |
분리기술 |
| 제목 |
A Study on The Solubility and Recrystallization of Ibuprofen using Supercritical Fluid |
| 초록 |
Ibuprofen is a chiral nonsteroidal anti-inflammatory drug that is used to treat arthritis, fever and headaches. The drug must be soluble in the water for bioavailability. But ibuprofen has poor solubility in water. The dissolution rate of a drug in the biological environment can be improved by reducing the particle size of the drug. The rapid expansion of supercritical solution (RESS) is process that reduces the particle size using the supercritical fluid. We tried to micronize ibuprofen using RESS process. The solubility of ibuprofen in supercritical fluid was measured prior to perform the RESS process for accurate experiment design. The solubility was measured using variable volume view cell. The solubility result was correlated by the simplified Peng-Robinson equation for the mole fraction at saturation of a solute of low volatility forming dilute solution in the supercritical fluid. The particle size and morphology of processed particles were analyzed by the Scanning Election Microscopy and Particle Size Distribution Analyzer. |
| 저자 |
김영애, 주준호, 김화용, 이윤우
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| 소속 |
서울대 |
| 키워드 |
supercritical fluid; ibuprofen; solubility; recrystallization
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| E-Mail |
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| 원문파일 |
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