| 초록 |
In this talk, we introduce new substances and techniques to prevent post-surgical adhesion formation using photocurable hydrogles. Peritoneal administration of photocurable hydrogel and bi-layer hydrogel appears to prevent post-surgical adhesions. We hypothesize that an adhesion barrier, which also delivers anti-adhesion drugs, can address both physical and physiological causes for adhesion formation. Here, we used an in situ photocurable natural polymeric hydrogels such as hyaluronic acid, chitosan or alginate, or bi-layer hydrogels (barrier device) containing the transilast. Transilast was chosen due to its well-known role of anti-inflammation in adhesion formation, and natural polymers were chosen due to their good biocompatibility in a peritoneum. Thus, photocurbale hydrogel and bi-layer hydrogel with the transilast have a strong potential as anti-inflammation barriers for the prevention of post-surgical adhesion. |
