| 초록 |
The hypothalamus is a key neuroendocrine system known to regulate energy homeostasis via the orchestrated actions of neuronal pathways and neuroendocrine hormones that regulate energy balance and nutrient homeostasis. Nutritional status exerts important effects on various types of hypothalamic signaling, such as insulin and leptin pathways, and hypothalamic dysfunction is a critical cause of metabolic syndrome and its related diseases, including aging. It has been proposed that hypothalamus helps to control aging. Hypothalamic stem/progenitor cells were observed with a substantial loss of these cells. Conversely, aging retardation and lifespan extension were achieved in mid-aged mice that were locally implanted with healthy hypothalamic stem/ progenitor cells and their microRNAs. In conclusion, the treatment to hypothalamus with specific factors, including hypothalamic stem/ progenitor cells and exosomal microRNAs, contributes to control metabolic function and disorders. |
