| 초록 |
Crystallization of GMP by downing-out was investigated using methanol as an anti-solvent in Couette-Taylor crystallizer for production of GMP crystals at room temperature. Generally, the crystallinity, mean crystal size and the recovery are strongly influenced by fluid dynamic conditions via perfect mixing in the crystallizer. This paper examined the effects of mixing properties of Taylor vortex on the crystallinity, mean crystal size and the recovery of GMP solution. In order to do this, the crystallization process was observed under different working conditions by varying the concentration of reactant, the agitation speed of the inner cylinder and the geometry of reactor. We find that fluid dynamic conditions resulting from the rotating speed of the inner cylinder and the geometry of crystallizer, play the key role in the dissolution of amorphous transformation to GMP crystals and the nucleation-growth of GMP crystals. Our experimental results indicate that the crystallization of GMP can obtain one hundred percent of crystallinity and recovery at 300rpm. Particularly, the crystallization of GMP in liquid-liquid Couette-Taylor crystallizer by drowning-out can be predicted from the operating conditions. |
