| 초록 |
Gelatin derives from collagen which is known as major component of natural ECM. Since it has the benefits of biocompatibility, biodegradability, and low immunogenicity thanks to tripeptide RGD motif, gelatin is regarded as promising material in various applications such as tissue engineering. However, in order to broaden its application, gelatin needs to be crosslinked or blended with other polymers due to its poor mechanical properties. Alginate is one of the natural polysaccharide extracted brown algae and readily fabricated by ionic interaction between poly(guluronate) blocks and divalent cations. In this study, we synthesized oxidized alginate via periodate oxidation and prepared oxidized alginate/gelatin crosslinked fiber through wet spinning under CaCl2 coagulant. The structure of the fiber was investigated by 1H-NMR, FT-IR, FE-SEM. Furthermore, several experiments for the identification of the stability of blend fiber including UTM were performed. |
