| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
ECM-mimetic topographic substrates as cell chips for in vitro cytotoxicity test platforms |
| 초록 |
Pre-clinical trial including in vitro and in vivo animal testing is essential to find out the cytotoxicity, and it is also important to screen out the candidates in new drug development. In this study, we propose the extracellular matrix (ECM)-mimetic topographic substrates as new pre-clinical trial platforms for investigating anticancer drug-induced cytotoxicity of stem cells. The morphologies and behaviors of stem cells were controlled by the ECM-mimetic topographic substrates, eventually affecting the cells fate (i.e., survival and death) against the common chemotherapeutic agent cisplatin. Most importantly, the cisplatin-induced cytotoxicity was prevented by the appropriate inhibited gap junctions of stem cells on the ECM-mimetic topographic substrates unlike the flat substrates. Our finding demonstrated the ECM-mimetic topography may be a crucial parameter for cytotoxicity test, which can be used as new pre-clinical trial platforms in drug development. |
| 저자 |
Sunho Park, Daun Kim, Woochan Kim, Sujin Kim, Sungmin Park, Jangho Kim
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| 소속 |
Chonnam National Univ. |
| 키워드 |
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| E-Mail |
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