| 초록 |
Although azidothymidine(AZT) is the first approved antiretroviral drug for the treatment of HIV, it fails to be targeted and sustained in lymphatic tissue, and has drug resistance as well as serious side effects, such as bone marrow suppression, peripheral neuropathy, and mitochondrial myopathy. In this work, anti-HIV active triblock copolymers were synthesized by the polymerization of 5'-O-itaconyl-AZT with the polyrotaxane as a macroinitiator, in which many β-cyclodextrins were threaded onto a poly(propylene glycol) via atom transfer radical polymerization(ATRP). The in vitro antiviral activities of the copolymers were determined and used to evaluate the potential applications in anti-AIDS drugs. |
