| 초록 |
Fluorescent nanodiamonds (FNDs) are promising probesfor biomedical imaging due to their excellent properties. However, thecolloidal stability of FND in salt aqueous buffer is mediocre, and the surface modificationwith functional agents remains challenging. Here, we present the encapsulationof FNDs into polydopamine (PDA) shells. The PDA shells allow furthermodification via Michael addition or Schiff base reactions with other moleculescontaining thiol or nitrogen derivatives. We demonstrate PDA shells can bemodified by thiol terminated polyethylene glycol (PEG) molecules to enhancecolloidal stability in biological solutions and biocompatibility of PDA coatedFND (FND@PDA). The PEG functionalized FND@PDA is employed as a fluorescentprobe for imaging immature bone marrow derived dendritic cells. Furthermore,biotin‐PEG‐SH modified FND@PDA nanoparticles, tethered to biotinylated DNAs, enablea long‐term and high‐resolution tracking of individual DNA molecules. |
