| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 봄 (04/24 ~ 04/26, 제주국제컨벤션센터) |
| 권호 |
25권 1호, p.372 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
RNA Three-Way Junction on Ag@Bi2Se3 for Neuroblastoma Differentiation |
| 초록 |
Nanoparticle-based cell differentiation therapy has gained huge attention as a promising alternative to traditional cancer treatments. Biocompatibility and plasmonic features were remarkably represented by the topological insulator bismuth selenide nanoparticle (Bi2Se3 NP) was core-shelled with silver (Ag@Bi2Se3). Moreover, the newly developed RNA three-way junction structure (3WJ) was designed for the quad-functionalization of nanoparticle and surface. One leg of the 3WJ was attached to the Ag@Bi2Se3, another leg to RNA with fluorescence tag, and the other leg was assigned to inhibit microRNA-17 (miR-17) and to release retinoic acid (RA). This new drug delivery system was developed based on the slow release of RA through inhibition of miR-17 within cytosol. A simple method to solve the hydrophobicity challenges of RA was reported through a stimulus-responsive cross-linker. The developed nanobio hybrid material could completely differentiate SH-SY5Y cancer cells into neurons and stop their growth in 6 days without sequential treatment. The fabricated nanobiohybrid material can be a new platform in the fabrication of different diagnostic/therapeutic agents. |
| 저자 |
이찬용, 김동연, Mohsen mohammadnaei, 최정우
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| 소속 |
서강대 |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
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