| 초록 |
Dimethyl sulfoxide (DMSO) was one of the important solvents in biological and as medicine for transdermal delivery enhancers. PolyDMSO has inspired by the good biological properties of DMSO, like a highly hydrophilic, and good transdermal delivery. We study has focused on delivery enhancers and antimicrobial properties of fabricated nanofiber patch. First, poly(2-(methylsulfinyl)ethyl acrylate (PMSEA) nanofibers predicted transdermal delivery enhanced properties because PMSEA was analogs of DMSO properties. Second, the poly(ε-caprolactone)/[2-(methacryloyloxy)ethyl] trimethylammonium (PCL/MTA) nanofibers expected to protect the wound site against external infection. Finally, transdermal delivery enhanced nanofibers (PMSEA/PCL-MTA) were confirmed mechanical tests, Fourier-transform infrared spectroscopy (FT-IR), 1H Nuclear Magnetic Resonance (1H-NMR), Field-emission Scanning Electron Microscopy (FE-SEM), water contact angle, Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA), and antimicrobial test. |
