| 초록 |
Graphene oxide (GO) is an allotrope of carbon family. GO sheets are 2-dimensional atomically thin nanosheets and have been studied for bio applications attribute to their unique physiochemical properties such as high surface area, functional oxygen moieties, amphiphilicity and concentration-dependent cytotoxicity. The presence of the oxygen moieties on the surface allows easy modification to GO sheets with a variety of functional materials. 2-dimensional anti-cancer drug delivery with GO sheets have been widely reported. However, drug delivery with one dimensional GO scrolls has not studied yet. In this research, we functionalized doxorubicin (DOX) onto the 2-dimensional GO sheets by physical and chemical interactions. We have investigated the cytotoxicity of GO scrolls and analyzed the loading efficiency of DOX in GO scrolls depending on their lateral sheet size. Furthermore, size-dependent and pH-dependent DOX release rate and cellular uptake mechanism with HeLa cells were studied. |
