| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy |
| 초록 |
Multifunctional nanoparticles integrating cancer cell imaging and treatment into a single platform are recognized as a promising approach. In this study, we synthesized magnetic field-inducible drug-eluting nanoparticles (MIDENs) by embedding superparamagnetic iron oxide nanoparticles (Fe3O4; SPIONs) and cancer therapeutic drugs (doxorubicin; DOX) in a temperature-responsive poly (lactic-co-glycolic acid) (PLGA) nanomatrix. The external alternating magnetic field (AMF) generated heat above 42 0C and subsequent transition of the MIDENs (Tg ~ 42- 45 0C) facilitating the controlled release DOX, ultimately allowing for simultaneous hyperthermia and local heat-triggered chemotherapy for efficient dual cancer treatment. In vitro and In vivo studies revealed that the MIDENs enabled significant suppression of malignant tumor growth under an AMF. To conclude will be greatly beneficial for cancer image-guided thermo-chemotherapy applications. |
| 저자 |
ANSUJA PULICKAL MATHEW, Cherukula Kondareddy, VEENA VIJAYAN, 박인규
|
| 소속 |
Chonnam National Univ. |
| 키워드 |
Cancer treatment; Theragnostics; Nanomedicine; Magnetic nanoparticles; Responsive material
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| E-Mail |
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