| 학회 | 한국재료학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 삼척 쏠비치 호텔&리조트) |
| 권호 | 25권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | In-vitro and In-vivo characterization of biphasic polymethylmethacrylate bone cement functionalized with hyaluronic acid-polyethylene glycol aqueous gel phase for vertebral compression. |
| 초록 | Abstract Polymethyl methacrylate (PMMA) has been widely used as an injectable biomaterial for orthopedic and neurological application. However, the major complications of PMMA bone cement are the increased fracture rate of the adjacent vertebral bodies, and the elevated polymerization temperature. The combination of aqueous gel phase with PMMA bone cement is suitable for the intended application. PMMA cement was prepared by using Hyaluronic acid (H) and Polyethyleneglycole (P), which act as an aqueous gel phase, and provide a major contribution for pore formation, as well as temperature decrease. The goal of this study was to investigate the effect of PMMA bone cement in the presence of aqueous gel phase in terms of superior mechanical properties, lower polymerization temperature, apatite formation, and improved biocompatibility. SEM images showed the solid and liquid phase uniformly distributed on the PMMA matrix. After SBF treatment for (7, 14, and 28) d, the mechanical strength and elastic modulus of PMMA-HP was significantly decreased. The degradation behavior results revealed after SBF treatment with PMMA-HP showed porous structure, whereas the PMMA-MMA had rigid, non-porous surface. In addition, aqueous gel significantly reduced the polymerization temperature from (63 to 52) °C. The aqueous gel phase maintained nearly physiological pH, which indicates its suitability for cell viability and proliferation. Further MTT and confocal data ensured the biocompatibility of PMMA-HP. In vivo rabbit vertebrae data revealed the osteointegration of bone cement. The results suggest that PMMA-HP bone cement possesses distinctive biomechanical and physiochemical properties, and is suitable injectable bone cement for the application of bone regeneration. |
| 저자 | Omar Faruq1, Byong-Taek Lee2, Soo-Bin Im3 |
| 소속 | 1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 | Polymethylmethacrylate; bone cement; vertebra; hyaluronic acid; polyethylene glycol |
