| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Sensing Intracellular behavior of ultrasmall, paramagnetic iron oxide-conjugated PEI/DNA polyplex by T2 Magnetic Relaxation Switch of Magnetic Resonance Imaging |
| 초록 |
Magnetic resonance (MR) imaging is a powerful tool for non-invasive monitoring due to its high resolution and use of non-ionizing radiation. The low innate contrast of biological molecules can be enhanced through contrast agents. Ultrasmall, superparamagnetic iron oxide (USPIO) have been widely investigated as T2 relaxivity MR constrast agents. These nanoparticles have been incorporated into drug delivery systems such as polymeric micelles and baculovirus for tracking in vitro and vivo. Here, we present the development of a novel hybrid nanoparticle formulation that integrates gene delivery with magnetic resonance contrast properties that are sensitive to the packaging state of the vectors. |
| 저자 |
박인규1, 정명호2, 안영근3, Chee Ping Ng4, Jinnan Wang1, Suzie H. Pun1
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| 소속 |
1전남대, 2Seattle, 3WA 98195, 4USA |
| 키워드 |
MRI; USPIO; T2 switch; Polyplex
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| E-Mail |
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