| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
pH Soluble Properties and Improvement of Dissolution Rate of Pranlukast by using Spray-driying with Plasdon S-630 |
| 초록 |
Solid dispersion of pranlukast was prepared by using spray-dryer with plasdone S-630. When pH of water is high, pranlukast is high soluble with water in solubility experiment of pHs with solid dispersion. PSA measures the pranlukast in solid dispersion from confirm a nano size of pranlukast. Zeta-potential measures solid dispersion from confirm a negative charge. SEM was used to observe surface of solid dispersion from confirm a sphere of solid dispersion, DSC and XRD were used to analyze the amorphous of solid dispersion. The in vitro test was carried out to find improved dissolution rate of pranlukast solid dispersion in intestinal juice and controlled experiment was carried out to compare pranlukast solid disperion with conventional drugs (Onon). These results suggest that the dissolution properties of pranlukast solid dispersion as the orally pharmaceutical formulation was prepared by spray drying. |
| 저자 |
김용기1, 강길선1, 홍민성2, 김혜린1, 조한수1, 이동원2
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| 소속 |
1전북대, 2전북대하교 |
| 키워드 |
kast; Spray-driying; Plasdon S-630; Dissolution Rate.
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| E-Mail |
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