| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Improvement of Prothionamide Dissolution by Solid Dispersionwith Complex Polymer |
| 초록 |
The purpose of this study, prothionamide synthesized with two polymers can improve release characterization with spray drying. The solid dispersion was formulated by added hydrophilic polyvinylpyrrolidone (PVP) for enhanced biocompatibility, and increased Eudragit®. SEM was used to observe surface of solid dispersion from confirm a sphere of solid dispersion, DSC and XRD were used to analyze the amorphous of solid dispersion. The in vitro test was carried out to find improved dissolution rate of prothionamide solid dispersion in intestinal juice and controlled experiment was carried out to compare prothionamide solid dispersion with original drug. These results suggested that we confirmed that the change of amorphous crystallization, the release characterization and the increase in dissolution rate follow the polymer ratio when the formulation prepared by spray drying. This research was supported by WCU (R31-20029) |
| 저자 |
송정은, 이윤미, 서한솔, 조원형, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Prothionamide; solid dispersion; amorphous crystallization
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| E-Mail |
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