| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Potential performance as a targeted antitumoral therapy using dihydroxyflavone-conjugated hyaluronic acid nanogels |
| 초록 |
We prepared Hyaluronic acid (HA)-based nanogels conjugated with Dihydroxyflavone (DHF) and evaluated their cellular uptake and antitumoral efficiency. HA-based DHF nanogels bound to the CD44 receptor can transfer 7,8-dihydroxyflavone to tumor cells through hydrolysis in low pH cancer cell environments. The size of the HA-based DHF nanogel was about 90 nm. We used HepG2, HeLa cells that overexpress the CD44 receptors. NIH3T3 was used as a control cell. In cytotoxicity analysis, HA-based DHF nanogel showed higher tumor cell death than control cell. These results show that our nanogel are valuable for cancer targeting drug delivery. |
| 저자 |
윤태훈, 최성욱
|
| 소속 |
가톨릭대 |
| 키워드 |
Nanogel; Hyaluronic acid; Dihydroxyflavone; Antitumor therapy
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| E-Mail |
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