| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
바이오리파이너리 기술의 최신동향 |
| 제목 |
Many Applications from One Enzyme: Engineering of Cytochrome P450BM3 Enzyme |
| 초록 |
Cytochrome P450BM3, a monooxygenase enzyme isolated from Bacillus megaterium, is a highly evolvable protein which can adapt new functions easily compared to many other enzymes. They are tolerable for many destabilizing new mutations and have conformationally variable nonpolar active sites. Wild-type P450BM3 enzymes lacking desired catalytic or physical properties have been extensively and successfully engineered for the synthesis of a variety of value-added products with new substrate scope and high selectivity. We will discuss recent advances in engineering of cytochrome P450BM3 focused on biocatalytic and biomedical applications. |
| 저자 |
정상택 |
| 소속 |
국민대 |
| 키워드 |
Cytochrome P450BM3; Enzyme; Directed Evolution
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| E-Mail |
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