| 초록 |
Biosensors, which convert a biological response into an electrical signal, are able to provide information to support various researches including drug discovery, proteomics, or environmental monitoring. In nearly all biosensors, interaction between targets and the sensor surface plays a critical role of detection and sensitivity in governing ultimate performance. Hence, we have focused on developing new methods to modify surface of biosensors utilizing nano-scaled materials. One of our approaches to modify neural electrodes takes advantage of recent developments in the synthesis, processing, and characterization of novel polymeric materials and the use of relevant ECM components. This entails the use of biocompatible polymers for creating of soft, electrically conductive, bioactive coatings that can be deposited onto the electrode shaft and modification of the electrode sites by high surface area morphology conducting polymers. Another approach applies to the chip-based, affinity biosensors which make use of the specific capabilities of an analyte to bind to a recognition element. These affinity biosensors require non-fouling, i.e. protein-resistant, surfaces to prevent adventitious adsorption resulting in compromising the sensitivity of the diagnostics. To date, the most common approach to reduce non specific protein adsorption on a surface is via a coating of poly(ethylene glycol) (PEG). Oligo(ethylene glycol) methacrylate (OEGMA), a PEG-like polymer synthesized by atomic transfer radical polymerization has shown remarkable increase of sensitivity due to low background noise. |
