| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Mesoporous silica nanoparticle based photo-responsive drug releasing system |
| 초록 |
Mesoporous silica nanoparticle (MSN) has been studied for a decade as a drug delivery carrier due to its surface-pore biphasic structure and high biocompatibility. Recently, light-responsive drug delivery system has been issued because light is the stimulus which is spatially and temporally controllable by modulating wavelength and power. However, the UV-light, which is generally used in bioapplication, is not appropriate for practical drug delivery system because it cause damage on tissue and has a low penetration depth to body. Herein, we prepared specific crosslinker which can be broken by long-wavelength light and then developed photosensitizer-loaded MSN linked with drug by using above-mentioned crosslinker. This material showed an improved drug releasing profile response to irradiation of long-wavelength light. There, it can be concluded that this novel concept shows the potential for further application of controllable drug delivery system. |
| 저자 |
이준석1, 박주희2, kaushik Singha2, 김원종2
|
| 소속 |
1POSTECH, 2포항공과대 |
| 키워드 |
mesoporous silica nanoparticle; photo-responsive; drug release
|
| E-Mail |
|
