| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Design of PpIX-conjugated pH-sensitive polymeric nanoparticles for Photodynamic Therapy |
| 초록 |
An effective tumor-targeted drug delivery system for photodynamic therapy was generated by designing ligand-mediated nanoparticles with stable formulations of a hydrophobic photosensitizer. Novel folic acid (FA)-conjugated amphiphilic block copolymers were synthesized. The 2,4-diacetyl deuteroporphyrin IX dimethyl ether (Pp IX)-conjugated amphiphilic block copolymers containing folic acid ligands were synthesized. Photosensitizer-loaded copolymeric nanoparticles (FA-PEG-P(Asp-Hyd)-Pp IX) were prepared by micelle formation in an aqueous solution. The results of in vitro release tests showed that the release profiles of Pp IX from the nanoparticles were strongly pH-dependent and influenced by the loaded amount of photosensitizer. FA-PEG-P(Asp-Hyd)-Pp IX nanoparticles were not cytotoxic without light and showed good cellular uptake. In addition, FA-PEG-P(Asp-Hyd)-Pp IX nanoparticles showed marked phototoxicity compared with free PpIX. |
| 저자 |
자오린린, 김소연
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| 소속 |
충남대 |
| 키워드 |
PEG; folic acid; nanoparticle; tumor targeting; photodynamic therapy.
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| E-Mail |
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