| 초록 |
Polydiacetylene-based supramolecules are interesting biomimetic materials in view of application to chemical and biological sensors. These conjugated supramolecules are unique in changing color from blue to red upon specific binding events. Various binding events including viruses, toxins, glucose, and ionic interactions have been reported detectible. However, simultaneous screening of various binding events has not been possible with solution-phase vesicles and solid-supported films of polydiacetylenes. In this presentation, we report on printing of the vesicles on glass to pattern dot arrays. Each dot is found to possess the color changing property as well as the fluorescence self-emission. This technique allows us, for the first time, to fabricate chemical and/or biochips based on polydiacetylene vesicles and to screen binding events simultaneously. Exemplary applications will be discussed for label-free detection of cyclodextrins, polyamines, DNAs, and proteins. |
