| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Co-production of 3-hydroxypropionic acid and 1,3-propandiol by recombinant Klebsiella pneumoniae |
| 초록 |
3-hydroxypropionic acid (3-HP) production from glycerol has gained much attention due to the importance of 3-HP as platform chemical. 3-HP production is composed of two reactions i.e. conversion of glycerol to 3-HPA oxidation to 3-HP. Klebsiella pneumoniae, one of the candidates for 3-HP production, has advantage of natural synthesis of B12 under anaerobic condition. However, further reaction of 3-HPA to 3-HP involves the reduction of NAD+ and consequently NAD+ regeneration is very important for efficient production of 3-HP. On the other hand, production of 1,3-PDO by NADH-dependent oxidoredcutase of K. pneumoniae has been studied extensively. Hence, in this study, we tried co-production of 3-HP and 1,3-PDO using K. pneumoniae mutants and studied the effect of various environmental factors and genetic backgrounds on co-production yields change in K. pneumoniae. |
| 저자 |
고연주, 설은희, Ashok Somasundar, 박성훈
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| 소속 |
부산대 |
| 키워드 |
3-hydroxypropionic acid; 1; 3-propanediol; Klebsiella pneumoniae
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| E-Mail |
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