| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 |
19권 1호, p.416 |
| 발표분야 |
생물화공 |
| 제목 |
Production of 5-aminovalerate and glutarate as C5 platform chemicals through metabolically engineered Escherichia coli |
| 초록 |
5-Aminovalerate (5AVA) is a C5 platform chemical and a precursor for nylon 5. Escherichia coli was metabolically engineered for the production of 5AVA and glutarate. When Pseudomonas putida davAB genes were introduced into recombinant E. coli, 0.5 g/L of 5AVA were produced from glucose by fed-batch culture. When recombinant E. coli expressing the davAB and gabTD genes was cultured in a medium containing 20 g/L glucose, 10 g/L l-lysine and 10 g/L α-ketoglutarate, 1.7 g/L of glutarate was produced. This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Education, Science, and Technology (MEST) through the National Research Foundation of KoreaNRF-2012-C1AAA001-2012M1A2A2026556). Further support from the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the MEST (2012–0006693) and the R&D Program of MKE/KEIT (10033199 and 10033386) is appreciated. |
| 저자 |
최소영1, 박시재2, 김은영3, 노 원3, 박혜민1, 오영훈3, 이승환3, 송봉근3, 제갈종건3, 이상엽1
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| 소속 |
1KAIST, 2명지대, 3한국화학(연) |
| 키워드 |
Metabolic engineering; 5-aminovalerate; glutarate
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| E-Mail |
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| 원문파일 |
초록 보기 |
