| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.443 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Inhibition of smooth muscle cell proliferation using curcumin-loaded PLGA nanoparticles |
| 초록 | Abstract Restenosis occurs in approximately 30-40% of patients following percutaneous transluminal coronary angioplasty (PTCA) for treatment of atherosclerosis. Proliferation of the smooth muscle cells from the arterial wall into the lumen of the artery is considered as a major cause of restenosis.1 In order to inhibit vascular smooth muscle cell proliferation, drug must be delivered at a high concentration for a prolonged period of time.2,3 Therefore, local sustained drug delivery systems have been under investigation to treat the regional pathophysiologic process of restenosis. 4-6 In this study, we evaluate the feasibility of local delivery of curcumin, an anti-proliferative drug of smooth muscle cells, using nanoparticles formulated with a biodegradable PLGA (poly (DL-lactide-co-glycolide)) as sustained-release system for the prevention of restenosis. Drug containing PLGA nanoparticles were prepared by the emulsification method. Variable factors such as the type and concentrations of stabilizer, sonication out-put, polymer concentrations, could be the important factors for the formation of PLGA nanoparticles. The release of the drug was sustained over 4 weeks in vitro, and the curcumin loaded PLGA nanoparticles showed an antiproliferative effect against smooth muscle cells comparable to free curcumin. References 1. Hassenstein, S., hanke, H., Kamenz, J., Oberhoff, M., Hanke, S., Riessen, R., Haase, K.K., Betz, E., Karch, K.R. Circulation, 1992, 86, 1575 2. A.W. Clowes, M.A. Reidy, and M.M. Clowes, Lab. Invest., 1983, 49, 327 3. E.R. Edelman and M.J. Karnovsky, Circulation, 1994, 89, 770 4. Lincoff, A.M., Topol, E.J., Ellis, S.G. Circulation, 1994, 90, 2070 5. Riessen, R., Isner, J.M. J.Am.Col.Cardil. 1994, 23, 1234 6. Axel, D.I. Gornick, C.C. Circulation, 1997, 96, 636 Acknowledgments This Work is supported by a grant of the National Research Laboratory(NRL) (Grant No. M10203000098-02J0000-0461 ) from the Ministry of Science and Technology, Korea. |
| 저자 | 강수정1, 손영덕1, 홍성유2, 장양수2, 정광회3 |
| 소속 | 1(주)바이오버드 국가지정 심혈관치료연구실, 2연세대, 3(주)바이오버드 국가지정 심혈관치료연구실 / 연세대 |
| 키워드 | Restenosis; smooth muscle cells; curcumin; nanoparticle; sustained-release system |
