| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
pH-sensitive polymeric micelle of MPEG-poly(β-amino ester) block copolymer |
| 초록 |
Poly (ethylene glycol) methyl ether(MPEG)-poly(β-amino ester) block copolymers were synthesized by Michael-type step polymerization and investigated for the construction of pH sensitive polymeric micelles (PM). The β-amino esters were used as a pH sensitive hydrophobic block while MPEG was used as a hydrophilic block. The structural properties were confirmed by 1H-NMR and gel permeation chromatography (GPC). The pKb values of the pH sensitive polymers were measured by the titration method. The solution properties were studied by spectrophotometry, fluorescence, and dynamic light scattering (DLS). The critical micelle concentration (CMC) at pH 7.4 decreases from 0.30mg/ml to 0.002mg/ml with the number of methyl group in bisacrylate increasing from 4 to 10. The pH dependent micelle behaviors were varied within narrow pH region with the various bisacrylate esters. The results obtained from DLS showed that the micelles have an average size below 100nm. These pH sensitive polymeric micelles developed may be a good carrier for anticancer drug delivery. |
| 저자 |
황수종, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
block copolymer; pH-sensitive; polymeric micelle; β-amino ester
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| E-Mail |
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