| 초록 |
Poly(N-isopropylacrylamide) (PNIPAAm) is one of the most studied stimuli-responsive polymer. PNIPAAm is a thermo-responsive polymer exhibiting a low critical solution temperature (LCST) behavior having a sharp transition temperature at 32℃ in aqueous solutions. When the nanoparticles are decorated by stimuli-responsive polymers, we can control the cellular uptake of nanoparticles in response to external stimuli. Herein, we synthesized QDs modified with PNIPAAm and cell penetrating peptide (CPP) using streptavidin-biotin interaction between streptavidin-coated QDs and biotin-conjugated PNIPAAm and CPP. At room temperature, PNIPAAm formed the hydrodynamic shell shielding CPP molecules, consequently inhibiting the cellular uptake of QDs. On the other hand, the PNIPAAm shell collapsed at 37oC, exposing the CPP molecules that initiate the cellular uptake of the nanoparticles. |
