| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.33 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Thermogelling biodegradable polymer aqueous solutions and their biomedical applications |
| 초록 | The block and graft copolymer composed of poly(ethylene glycol) (PEG) / poly(lactic-co-glycolic acid) (PLGA) has been developed as minimally invasive drug delivery and tissue engineering applications (1-5). The aqueous solution of these copolymers is a sol at room temperature or lower, but becomes a gel at body temperature (37 oC). Such a sol-to-gel transition accompanies changes in micellar aggregation as the temperature increases. The sol-to-gel transition could be controlled by molecular parameters such as PEG length, PLGA length, ratio of lactic acid to glycolic acid, and topological variations. Compared with the block copolymer system, the graft copolymer system shows more flexibility in the control of gel duration. PEG-g-PLGA shows short duration as a gel whereas PLGA-g-PEG shows much longer duration as a gel in-vivo. The model drug release from the in-situ formed gel could be described by a model assuming core-shell structure of the gel. The hydrophilic drug was mostly released by diffusion over one week, whereas the hydrophobic drug was released by diffusion followed by degradations over two months. The in-vivo study of protein delivery was investigated using insulin for diabetic rats. Depending on the composition of polymers, the hypoglycemic efficacy was observed over one week to two weeks. The chondrocyte suspension in the PEG/PLGA thermogelling aqueous polymer solutions shows very promising results for cartilage repair (6). To conclude, the PEG/PLGA polymer aqueous solution is very promising platform for protein delivery and tissue engineering applications. References 1. Jeong, B.et al. (1997), Nature,386:860-862. 2. Jeong, B.,et al. (1999). Macromolecules, 32: 7064-7069. 3. Jeong, B.,et al. (2000). Macromolecules ,33: 8317-8322. 4. Jeong, B.,et al. (2001). Chem. Comm. 1516-1517. 5. Jeong, B.,et al. (2001). J. Controlled Release, 63:155-163. 6. Jeong, B. et al. (2002). Biomacromolecules, 3, Web-ASAP. |
| 저자 | 정병문 |
| 소속 | 이화여자대 |
| 키워드 | theromogelling polymer; biodegradable; drug delivery; tissue engineering |
| VOD | VOD 보기 |
