| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of semi-interpenetrating polymer networks composed of chitosan and poloxamer |
| 초록 | The technology of tissue engineering has been developed to construct artificial tissues mimicking natural ones by combining modulated cells with various types of scaffolds, including natural and synthetic polymers. Chitosan (CS), one of natural polymers, not only has been reported some of its applications such as controlled release of drugs, chromatographic media, surgical thread, scaffolds, and wound dressings but also has been expected its application as artificial skin in tissue engineering. In an early stage, the aim of this work was to increase mechanical properties of chitosan sponge for wound dressing application by semi-interpenetration polymer networks (SIPNs) with poloxamer. After that, we’re progressing continuously its application as scaffold for artificial skin by tissue engineering. Through semi-interpenetration of polymer networks with poloxamer, mechanical properties of chitosan (CS) sponge were increased for wound dressing application. Synthesis of poloxamer macromer was confirmed by proton nuclear magnetic resonance (1H NMR) spectra. Possible interactions between chitosan and poloxamer in semi-interpenetrating polymer networks (SIPNs), and changes in crystalline structures of both polymers were evaluated by fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), respectively. Swelling behavior, thermal analysis, mechanical properties, and morphology of SIPNs were studied by thermal gravimetric analysis, differential scanning calorimetry (DSC), compressive modulus measurement, and scanning electron microscopy (SEM), respectively. Preparation of poloxamer macromer, and intermolecular hydrogen bonding between CS and poloxamer were confirmed by NMR and FTIR, respectively. Melting temperature of poloxamer in SIPNs decreased due to prevention of crystallization by incorporation of CS. Formation of SIPNs with poloxamer and increasing poloxamer content in CS/poloxamer SIPNs increased mechanical strength of CS sponge compared with CS/poloxamer blend. Formation of SIPNs with poloxamer remarkably increased water content of CS due to hydrophilicity of CS and poloxamer. These results suggest CS/poloxamer sponges prepared by SIPNs method have good possibility for wound dressing application owing to rapid water adsorption, high mechanical strength, and interconnected cross-sectional morphology of SIPNs. |
| 저자 | 김인용1, 유미경1, 김범철1, 김세권2, 이현철3, 조종수1 |
| 소속 | 1서울대, 2부경대, 3전남대 |
| 키워드 | Chitosan; Poloxamer; Semi-interpenetrating polymer networks; SIPNs; Wound dressing; Artificial skin |
