| 초록 |
The challenge for current photodynamic therapy (PDT) is efficientive treatment of cancers at a deep tissue level. The photosensitizers (PSs) used in conventional PDT are mostly activated by UV or visible light, which cannot pass through thick tissue due to the light absorption and scattering by biological tissues. The upconversion nanoparticles(UCNP)-based drug nanocarrier for PDT has widely accepted by researchers, because use of UCNPs as PS carriers would overcome the penetration distance of current PDT. In this study, the NIR-triggered UCNPs were synthesized by hydrothermal method. And then, block copolymers with targeting ligand were employed for modification of UCNP. The photophysical properties of UCNPs and morphology were determined. In addition, in vitro cellular localization, singlet oxygen generation and phototoxicity were investigated using MCF7 and A549 cell lines. |
