| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation of Biocompatible Zwitterionic PEG Grafted on Modified Nitinol-DLC Surface |
| 초록 |
Blood-compatible biomaterials have been of importance for a variety of medical applications. We have tested a Nitinol-DLC whose surface was grafted with zwitterionic PEG, with the aim of development of peripheral arterial stent. Poly(ethylene glycol) (PEG) is blood-compatible and sulfobetaine (-N+-SO3-), a zwitterionic polymer, is biocompatible as well. In this study, synthesized zwitterionic PEG was grafted on the Nitinol-DLC using an oxidation treatment. When the surface property and blood compatibility of surface-modified Nitinol-DLC was examined, the results showed that both contact angle and ratio of oxygen to carbon significantly decreased with the PEG-grafted Nitinol-DLC. The total amount of albumin adsorbed onto the TiNi-DLC-PEG2K-N+-S- was lower than that of TiNi-DLC control. The present study suggested that grafted zwitterionic PEG structure may possess an improved blood compatibility. |
| 저자 |
신홍섭1, 박귀덕1, 문명운1, 이광렬1, 김재진1, 김지흥2, 한동근1
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| 소속 |
1한국과학기술(연), 2성균관대 |
| 키워드 |
Stent; Nitinol-DLC; Zwitterionic PEG; Surface modification; Blood compatibility
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| E-Mail |
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