| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
생물공학 |
| 제목 |
Generation of disruption mutant of Rubradirin from the rubradirin producer streptomyces achromogenes var rubradiris NRRL 3061 |
| 초록 |
Rubradirin, as ansamycin antibiotic has been isolated from Streptomyces achromogenes var rubradiris NRRL 3061. It consists of four distinct structural moieties. Amide bond present in the structure of rubradirin plays an important role as a linkage between the coumarin ring and didipicolinic acid moiety of the rubradirin. We disrupted the amide bond present in the structure of rubradirin and then analysed the production of rubradirin and its mutated product with respect to the wild strain. It was observed that the formation of rubradirin could not take place in mutant whereas rubransarol production was distinctly observed. The rubransarol containing fractions and the native rubradirin were detected by HPLC. |
| 저자 |
이희찬, 류광경, 송재경, Janardan Lamichhane
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| 소속 |
선문대 |
| 키워드 |
streptomyces achromogenes var rubradiris; Rubradirin; rubradiris
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| E-Mail |
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