| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Organic-inorganic nanocarriers based on spatially-selective mineralization of self-assembled nanotemplates |
| 초록 |
The controlled deposition of nanophase inorganic components on self-assembled organic nanotemplates has broadened the choice of new functional nanocarriers for bioactive agents. In this study, we describe the spatially selective mineralization of self-assembled nanotemplates to produce highly biocompatible, robust hybrid nanocarriers that can release anticancer drugs in a specific cellular condition. Core-shell-corona polymer micelles of poly(ethylene glycol)-b-poly(L-aspartic acid)-b-poly(L-phenylalanine) act as a nanotemplate for calcium phosphate mineralization. PAsp middle shells with anionic nano-domains served as a spatial template for mineralization to form a calcium phosphate (CaP) layer. CaP middle layers can protect drug release efficiently at extracelluar environments but dissolve in endosomal/lysosomal compartments to facilitate intracellular drug release. This organic-inorganic nanoparticle can potentially be used as a novel specific intracellular drug carrier. |
| 저자 |
이홍재1, 김성은1, 박치영2, 김철희2, 이상천1
|
| 소속 |
1요업기술원, 2인하대 |
| 키워드 |
self-assembled polymer micelles; calcium phosphate mineralization; intracellular drug carrier
|
| E-Mail |
|
