| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Novel pH-responsive polymeric micelles: A pontential for drug carrier vehicle |
| 초록 |
Polymeric micelles composed of pH-responsive block copolymers can strengthen the anti-tumor efficiency of a drug by accumulating in the target area. Site-targeted drug delivery system also can be used to achieve enhanced therapeutic effect and minimize the harmful side effect of the drug. In order to give pH sensitivity on the micelle, the amphiphilic block copolymer forming the micelle should be incorporated with a ionizable group. A basic group such as an amine is ionized at various pH below pKb and deionized at various pH above pKb. In this study, We synthesized methoxy poly(ethylene glycol)-poly(ß-amino esters) block copolymers with different molar ratios and various bisacrylate ester by Michael type step polymerization. we have selected Paclitaxel (PTX) as hydrophobic drug because PTX is an important anticancer drug used in clinical practice and exhibits strong cytotoxic activity against a variety of cancer types. |
| 저자 |
한종권, 황수종, 김민상, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
micelle; pH-responsive; ß-amino ester; Paclitaxel
|
| E-Mail |
|
