| 초록 |
The polymorphism of low molecular weight organic crystals can be controlled by kinetic and thermodynamic factors. Among the thermodynamic factors, different crystal forms may result from a variation in the crystallization temperature or the type and concentration of additives. The crystallinity depends on the kinetic factors such as incubation time, feeding rate of non-solvent, etc. To understand the relationship among the factors, the crystallization of 5'-guanosine monophosphate (GMP) was performed using methanol as a non-solvent in 96-well plates or on patterned polymer substrates. Polyethylene glycol was used as an polymeric additives. The size and the kind of GMP were analyzed by optical microscopy, X-ray diffraction, atomic force microscopy. It was obtained that the concentration of methanol affects the number of nucleus, and the concentration of PEG affects the size of crystals. Temperature and incubation time were associated with the kind of crystals (4 H2O GMP, 7 H2O). |
