| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Synthesis of Dendritic Poly(ethylene glycol) Using Anionic Polymerization Method for Biomedical Applications |
| 초록 |
Poly(ethylene glycol)(PEG) polymers are non-toxic, water soluble, chemically stable, and resistant to immune response that have potential applications in biomedicine and pharmaceutical areas. The introduction of PEG into the dendritic structure, it has different structure, for example smaller hydrodynamic volume and spherical shape, may has additional advantages compared to linear PEG. Dendritic PEGs were synthesized by living anionic ring opening polymerization of ethylene oxide. Anionic polymerization is the most powerful method to obtain well defined structure. Dendritic PEGs were synthesized by divergent method and each generation was carried out in THF using diphenylmethyl potassium (DPMK) catalyst. Allyl bromide was introduced to polymeric chain ends and dihydroxylation was carried out for branch point. Focal point and end groups were functionalized for biomedical application. All generations were characterized by 1H NMR spectroscopy and GPC. |
| 저자 |
김주은1, 강정규1, 정지헌1, 변영로1, 김정안2, 안철희1
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| 소속 |
1서울대, 2경희대 |
| 키워드 |
PEG; dendrimer; anti-fouling
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| E-Mail |
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