| 초록 |
Developing hierarchically structured biomaterials with controlled chemical and physical properties is important to regenerative medicine. Despite advances in assembly processes, our ability to control hierarchical assembly using fibrillar biomolecules remains limited. Here, we developed a bioinspired approach to create collagen-like materials through directed evolutionary screening and self-assembly. We synthesized peptide amphiphiles by coupling phage display-identified collagen-like peptides to long-chain fatty acids. We then assembled the amphiphiles into diverse, hierarchically organized, nanofibrous structures using self-assembly based on liquid crystal flow and its controlled deposition. The resulting structures directed the growth of bone cells and hydroxyapatite biominerals. We believe our strategy could prove useful in the structural design of tissue regenerating materials. |
