| 초록 |
Polymer cubosome is a highly ordered periodic porous polymer nanostructure with large-pore networks composed of inverse cubic mesophases of block copolymer bilayers. Due to its large surface area, it has a potential to be used in separation, catalysis, drug delivery and nanotemplating by the introduction of desired functional groups on its surface. Herein, we describe the synthesis of branched-linear block copolymers having hydrophilic blocks composed of three poly(ethylene glucol)s with an alkyne end group. These block copolymers self-assemble in aqueous solution to provide well-defined polymer cubosomes with densely populated surface functional groups. To utilize the large surface area od functionalized polymer cubosomes as affinity-based separation of biomolecules, we introduced modified boronic acids to the acetylene groups at the surface of polymer cubosomes by click chemistry. The resulting structures showed a promise for separation of glyco-proteins. |
