| 초록 |
Cryogels have received much attention in tissue engineering because of their useful properties of hydrophilicity and macroporous interconnected microstructures. Cryogels can be fabricated to allow interconnected pores of adequate size for the ingrowth of blood vessels and perivascular tissue. Furthermore, cryogels can be tailored to enhance cell-cell interactions, resulting in accelerated ECM deposition for newly formed bone tissues. In this study, we report a novel whitlockite reinforced chondroitin sulfate-based cryogel for biomimetic bone scaffold. Chondroitin sulfate, a negatively charged ECM molecule, can interact with many positive charged proteins and deposition of ions like calcium. Also, it can modulate the bioavailability of growth factors and cytokines by presenting them by forming protein gradients around the cell. CS-based hydrogel was reinforced with whitlockite, the second most abundant mineral in living bone, which provided an ideal environment for stem cells. |
