| 초록 |
In this study, we describe an in situ, injectable, electrostatic, cross-linkable hydrogel with curcumin (Cur) loaded microcapsule (Cur-M) to enhance anticancer activity. The carboxymethyl cellulose (CMC) and chitosan (CHI) solutions existed as a liquid before blending and formed a hydrogel as a drug depot after mixing via electrostatic interactions between the anionic CMC and cationic CHI. The electrostatic, cross-linked hydrogel depot persisted in vivo for an extended period. The prepared Cur-M was easily mixed with the CMC and CHI solutions. Cur-M/CMC and Cur-M/CHI solutions easily formed Cur-M-loaded hydrogel after simple mixing. The Cur-M-loaded hydrogel produced greater inhibition of tumor growth than did Cur-M, while single and repeated injections of free Cur had the weakest inhibitory effects. The results of this study indicate that the electrostatic, cross-linked, Cur-M loaded hydrogel can synergistically enhance anticancer activity in chemotherapeutic delivery systems. |
