| 초록 |
Abstract Microwave-assisted solid-liquid extraction of paclitaxel from Taxus chinensis has been investigated to understand the effect of microwave power and temperature on kinetics and thermodynamics of extraction. The paclitaxel concentration-time data were analyzed using various kinetic models to determine extraction constant. A diffusion model was utilized to determine diffusion coefficient taking into account of both washing and diffusion phases together. The thermodynamic analysis showed that the enthalpy change (ΔH^0) and entropy change (ΔS^0) were both positive, while the Gibbs free energy change (∆G^0) was negative and decreased when increasing the temperature and microwave power. The results indicated that the microwave-assisted extraction process for recovering paclitaxel from biomass was endothermic, irreversible, and spontaneous. Acknowledgment This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant Number: 2015016271). |
