| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Effect of Acidifier on the Dissolution Property of a Solid Dispersion of Raloxifene HCl |
| 초록 |
Hydroxypropylmethylcellulose(HPMC)-based, solid dispersions (SDs) and physical mixtures (PMs) were prepared to enhance the dissolution rates of poorly water-soluble drugs. The roles of the acidifiers on structural crystallinity, drug dissolution rate were investigated. A poorly water-soluble drug, raloxifene HCl (RXH), was used as the model drug. The SDs and PMs were prepared with HPMC, drugs and acidifiers using the spray-drying method and then compressed into tablets. Scanning electron microscopy (SEM) was used to analyze the surface morphology of the SD and PM samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystallinity of SDs. Fourier-transform infrared spectroscopy (FT-IR) was used to analyze characteristic the change of chemical structure of SD. The in vitro release behavior of SDs and PMs was examined in simulated gastric fluid. This research was supported by WCU (R31-20029). |
| 저자 |
심정보, 김형석, 조한수, 강수지, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
HCl; acidifier; solid dispersion; solubility; dissolution rate
|
| E-Mail |
|
