| 초록 |
Many studies have demonstrated that soluble growth factors would be critical in regulating proliferation and differentiation of stem cells. It is postulated that continuous release of growth factors may not be enough in eliciting a fully differentiated state of stem cells and therefore a temporally and spatially controlled release system is a challenging alternative. In this study, we designed a dual growth factor delivery system that is featured with a core-shell microcapsule composed of PLGA and alginate. Our hypothesis is that the proposed delivery system can be very useful in improving and regulating differentiation potential of stem cells. Under a high electric voltage condition, each PLGA emulsion and alginate solution was producing microcapsules of inner PLGA and outer alginate. When bioactive factors, such as BMP-2 and dexamethasone were loaded into each domain, their release profiles were found significantly different, based on their spatial position within the microcapsules |
