| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Enhanced myelination of pluripotent stem cell-derived oligodendrocytes on extracellular matrix-modified nanofibrous scaffolds |
| 초록 |
Previously there have been few studies to enhance myelination process of stem cells via tissue-engineering strategies. In this study, we developed a functional culture platform which is composed of extracellular matrix (ECM) and electrospun nanofiber scaffolds to facilitate myelination process between human iPSC-derived oligodendrocytes and induced neuronal cells. Our results indicated that ECM-functionalized nanofibrous scaffolds efficiently guided myelination of hiPSC-derived oligodendrocytes co-cultured with iN cells by promoting cellular alignment and interactions along the nanostructures. In conclusion, we suggest that in vivo-like ECM-modified scaffolds can efficiently provide a functional myelination platform, which has huge potential to apply for demyelination disease modeling and regenerative medicine for the treatment of demyelination diseases. This work was supported by grants (2016M3C9A4921712 and 2015M3A9B4071076) from the National Research Foundation of Korea (NRF). |
| 저자 |
조안나, 김수란, 진윤희, 조승우
|
| 소속 |
연세대 |
| 키워드 |
Stem cell engineering; ECM; nanofiber
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| E-Mail |
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