| 초록 |
Biodegradable polymers and hydrogels have been increasingly applied in a variety of biomedical fields and pharmaceutics. α,β-Poly(N-2-hydroxyethyl-DL-aspartamide), PHEA, is one of poly(amino acid)s with hydroxyethyl pendants, which is known to be biodegradable and biocompatible. Also this material can be structurally modified for useful biomedical applications via simple derivatization reactions. In this work, hydrogel materials based on PHEA were prepared by the crosslinking reaction of hmw polysuccinimide, the precursor polymer, with oligomeric PEG and PEI-diamines and the subsequent nucleophilic ring-opening reaction by ethanolamine under controlled reaction condition. The preparation of gels and their swelling behavior varing in different medium, temperature and pH, are investigated. Also some results on the hydrolytic degradation and the release behavior using a model drug will be included. The PHEA-based hydrogel has potential for a useful biomaterial as well as a substrate for current drug delivery system.
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