| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Growth Factor/Antibiotic-loaded PCL/HA Microsphere-Hydrogel System for Effective Bone Regeneration |
| 초록 |
Recently, various studies have been conducted for bone regeneration using microspheres as a bone substitute material. Polycaprolactone (PCL) is widely used as a bone substitute (filler) material, however, it poses poor osteoconductive capacity for bone regeneration. Hyaluronic acid (HA) is a naturally occurring non-immunogenic glycosaminoglycan and plays a significant role as a facilitator of osteogenesis for stem cells. In this study, we fabricated PCL/HA hybrid microspheres by a spray/precipitation method using a double nozzle spray. And we prepared a BMP-2-loaded PCL/HA hybrid microspheres and vancomycin-loaded alginate hydrogel carrier system as an injectable bone filler. The bone regeneration behavior of this BMP-2- and vancomycin-loaded bone filler was investigated using a skull defect model of rat. The BMP-2- and vancomycin-loaded group showed more enhanced bone regeneration than the control group (w/o BMP-2 and vancomycin) and the group with single BMP-2 or vancomycin. |
| 저자 |
신준영1, 장희윤1, 김세현1, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
Bone regeneration; Growth factor; Antibiotic; Microsphere; Hydrogel
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| E-Mail |
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