| 학회 |
한국재료학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 삼척 쏠비치 호텔&리조트) |
| 권호 |
25권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
In vitro evaluation of extracellular matrix coated electrospun membrane for vascular tissue engineering application |
| 초록 |
Polycaprolactone (PCL) and Extracellular matrix(ECM) are widely used for tissue engineering applications due to their excellent mechanical properties and biocompatibility. The aim of this study is to develop a simple approach for ECM coating on PCL-mPEG electrospun membrane for vascular tissue engineering application. PCL is fist modified with Poly ethylene glycol methylether(mPEG) to make PCL-mPEG electrospun membrane. Then the membrane is further coated with ECM using a simple approach and compared with uncoated samples. Biological evaluations were assessed by rat bone marrow mesenchymal stem cells(RBMSC) and differentiation of the cells were induced by vascular endothelial growth factor(VEGF) and platelet-derived growth factor(PDGF) for endothelial cell and smooth muscle cell respectively. ECM coated PCL-mPEG membrane is a promising way to enhance mechanical and biological properties for vascular tissue engineering. |
| 저자 |
Gyeong-Jin Joo1, Tamanna Sultana2, Myeong Ki Park3, Byong-Taek Lee4
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| 소속 |
1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ., 4South korea |
| 키워드 |
Electrospinning; Vascular tissue engineering; Extracellular matrix; PCL; PCL-mPEG
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| E-Mail |
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